Executive Summary

COEURATIVE, Inc. is a privately owned pharmaceutical development company incorporated in Virginia on December 17, 2012, and subsequently domesticated in Delaware on October 17, 2014. COEURATIVE was formed to create and develop curative strategies for the management of cardiovascular diseases related to cellular hypoxia.

Cellular hypoxia can be defined as a lack of oxygen at the level of individual cells, not necessarily related to a lack of oxygen at the level of a whole organism or an environment. Most cardiovascular diseases involve a deficiency of oxygen delivery to cells (cellular hypoxia.) The market for products that facilitate long-term management of these conditions will grow along with the population of patients. A successful compound should generate an average of $2 billion a year for ten years after ten years of development.

Opportunity

Heart and blood vessel diseases remain the leading causes of death in the developed world. There are still substantial opportunities for clinical development of small molecule compounds for treatment and prevention. Health care providers point with some pride to the substantial decreases in the death rate due to cardiovascular diseases. The truth is that our success creates a new problem: people who used to die of these diseases are now becoming chronic patients in need of long term management. Cardiovascular diseases are growing in prevalence and will continue to be the most significant public health challenge.

Pharmaceuticals are the primary pathway for treatment of chronic cardiovascular diseases.  The American Heart Association estimates that by the year 2030, there will be a 21.9% increase in the prevalence of stroke, and an 18% increase in the prevalence of coronary heart disease compared with 2013.

Product

Although the costs of caring for this patient population may become increasingly burdensome, pharmaceuticals will remain the most cost-effective strategy for long-term management of chronic cardiovascular diseases. Clinical development of new pharmaceuticals will remain an area of intense business interest. COEURATIVE is developing a new class of pharmaceuticals based on twenty years of research on the regulation of hypoxia-mediated events in blood vessels.

OXIMETRICANS (patent pending) are activated by the level of oxygen in cells and facilitate beneficial responses in the inner lining of the blood vessels (including anti-inflammatory and vasodilatory effects) in response to cardiovascular diseases associated with oxygen-mediated stress. We believe these drugs will reduce the incidence of myocardial infarction in patients with coronary disease, among other benefits.  The pre-clinical development of this novel class of agents is set to continue with drug delivery in human cell culture to define the triggers of activity in cellular models of cardiovascular disease.

John F. Schmedtje Jr.
President and CEO
Coeurative, Inc.
201 McClanahan Street SW
Roanoke, VA 24014

This document is not an offer or agreement to buy or sell securities, or a solicitation of an offer to buy or sell securities.  Any such offering or agreement will be made, if at all, pursuant to definitive subscription or other offering materials.

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